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Clinical Correlates and Prognostic Value of Different Metastatic Sites in Gastric and Colorectal Signet Article

Jingjing Wu, Daiqiong Fang, Da Man, Wenrui Wu, Qing Wang, Yating Li, Jianzhong Ye, Lanjuan Li

Engineering 2020, Volume 6, Issue 9,   Pages 1028-1034 doi: 10.1016/j.eng.2020.06.007

Abstract:

Gastric signet ring cell carcinoma (SRCC) and colorectal SRCC are the most aggressive histologicalpopulation-based study to analyze the metastatic patterns of SRCC and further estimate its contribution to the cancer-specificsurvival of gastric SRCC and colorectal SRCC.In gastric SRCC, distant lymph nodes were the most common metastatic sites.In summary, metastasis is a major contributor to cancer mortality in SRCC.

Keywords： SEER Program     Survival analysis     Signet ring cell carcinoma     Metastases     Colorectal cancer     Gastric cancer    

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Effect of gastric fluid on adsorption and desorption of endocrine disrupting chemicals on microplastics

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 8, doi: 10.1007/s11783-022-1525-8

Abstract:

• Effect of gastric fluid on EDCs adsorption-desorption to microplastics

Keywords： Microplastics     Gastric fluid     Endocrine-disrupting chemicals     Adsorption     Desorption    

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From gut changes to type 2 diabetes remission after gastric bypass surgeries

Bing Li, Xinrong Zhou, Jiarui Wu, Huarong Zhou

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 191-200 doi: 10.1007/s11684-013-0258-2

Abstract: We review the evidence on the relationship between the gut and T2DM remission after gastric bypass surgeryHowever, the exact changes and their relative importance in the metabolic improvements after gastric

Keywords： gastric bypass     T2DM     gut    

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MSI/LOH and extron expression of the FHIT gene in gastric carcinoma

XIAO Yuping, MAO Lili, HAN Chengbo, LI Jinyi, XU Lei, XIN Yan

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 99-103 doi: 10.1007/s11684-007-0019-1

Abstract: microsatellite instabilities (MSI), as well as extron expression of the fragile histidine triad (FHIT) gene in gastriccarcinoma (GC), in order to evaluate their association with clinicopathological processes in gastricFHIT were detected by using PCR at 4 microsatellite loci: D3S 1300, D3S 4103, D3S 1481, D3S 1234 in cancerwas no correlation between LOH and MSI of the FHIT gene in GC and the histological characteristics of gastricsuggest that LOH and MSI of FHIT gene may induce aberrant extron expression, which might play a role in gastric
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Effect of oxytocin on gastric ischemia-reperfusion injury in rats

ZHANG Wenwen, ZHANG Jianfu, ZHANG Yongmei, XU Ming

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 433-437 doi: 10.1007/s11684-007-0085-4

Abstract: The effect of peripherally administered oxytocin (OT) on gastric ischemia-reperfusion injury (GI-RI)and then released to allow reperfusion for 1 h, and the degree of GI-RI was assessed by scoring the gastricmucosal damage index (GMDI), the gastric fluid output, gastric fluid output, gastric acidity were measuredfluid output and the gastric acidity (evaluated by pH) of the control group were (430.17±87.36) μL,juice output and the depression of gastric acidity.

Keywords： control     significant difference     surgical     statistical significance     Sprague-Dawley    

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Data mining of microarray for differentially expressed genes in liver metastasis from gastric cancer

Ling XU MM, Feng WANG MM, Xuan-Fu XU MD, Wen-Hui MO BM, Rong WAN MD, Chuan-Yong GUO MD, Xing-Peng WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 247-253 doi: 10.1007/s11684-010-0027-4

Abstract: Tumor metastasis is the leading cause of death for gastric cancer.Metastasis is the main reason for the failure of clinical treatment for gastric cancer.In order to find metastasis-related genes and abnormal signal transduction pathway of high-invasive gastriccancer, samples of gastric cancer with liver metastasis were collected for microarray detection; up-regulatedcancer were investigated by the Gene Cluster with Literature Profiles (GenCLip) analysis software.

Keywords： gastric carcinoma     metastasis     signal transduction     gene chips    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

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Characterization of the Gastric Mucosal Microbiota in Patients with Liver Cirrhosis and Its Associations Article

Yanfei Chen, Jing Guo, Chunlei Chen, Ding Shi, Daiqiong Fang, Feng Ji, Lanjuan Li

Engineering 2021, Volume 7, Issue 4,   Pages 507-514 doi: 10.1016/j.eng.2020.04.014

Abstract: In this study, the gastric mucosal microbiota of patients with liver cirrhosis and controls were analyzedIn H. pylori-negative subjects, gastric bacterial communities of healthy and cirrhosis cohortsAlthough the H. pylori-negative gastric mucosal microbiota showed considerable heterogeneity, associations between specific gastric microbiota and clinical characteristics could be observed.Previous EVL therapy might lead to a distinct structure of the gastric mucosal microbiota, thus aggravating

Keywords： Microbiome     Liver cirrhosis     Symptoms     Varices     Gastric endoscopy    

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Progress and challenges in RET-targeted cancer therapy

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 207-219 doi: 10.1007/s11684-023-0985-y

Abstract: Oncogenic RET fusions or mutations are found most often in non-small cell lung cancer (NSCLC) and inthyroid cancer, but also increasingly in various types of cancers at low rates.

Keywords： pralsetinib     selpercatinib     RET-alteration     lung cancer     thyroid cancer     tumor-agnostic therapy     drug    

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Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination

Lei Huang,Aman Xu

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 20-31 doi: 10.1007/s11684-016-0493-4

Abstract:

To date, gastric carcinoma (GC) is one of the common and fatal digestive malignancies worldwide.The detection of gastric juice pH, fluorescence spectrum, cytology, Helicobacter pylori-associatedParticularly, early GC may be efficiently screened using gastric juice.Gastric fluid markers should be further studied to reveal the early predicators of malignancy and complications

Keywords： gastrointestinal fluid     gastric carcinoma     biomarker     diagnosis     prognosis     gastrectomy     adverse events    

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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 361-373 doi: 10.1007/s11684-018-0656-6

Abstract: termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancerinvasiveness, drug-resistance and the ability to form metastases at distant organs, and thereby contribute to cancer

Keywords： epithelial-to-mesenchymal transition     cancer     metastasis     cancer stem cell    

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Metformin for cancer prevention

Yonghua Yang

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 115-117 doi: 10.1007/s11684-011-0112-3

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Orlistat induces ferroptosis-like cell death of lung cancer cells

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 922-932 doi: 10.1007/s11684-020-0804-7

Abstract: synthesis is involved in the progression and treatment resistance of many types of cancers, including lung cancer; however, targeting the lipogenetic pathways for cancer therapy remains an unmet clinical need.we tested the anticancer activity of orlistat, an FDA-approved anti-obesity drug, in human and mouse cancerand we found that orlistat, as a single agent, inhibited the proliferation and viabilities of lung cancerand other types of cancer.

Keywords： orlistat     ferroptosis     FAF2     lung cancer    

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract:

The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance. Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling pathway. Intriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drug action and sensitivity. An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients, and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.

Keywords： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Frontiers of Medicine doi: 10.1007/s11684-023-1050-6

Abstract: Pancreatic cancer, notorious for its late diagnosis and aggressive progression, poses a substantial challengeThis review endeavors to furnish a holistic insight into pancreatic cancer, encompassing its epidemiologyand explore recent research advancements in precursor lesions and molecular subtypes of pancreatic cancerAdditionally, we highlight the development and application of multi-omics approaches in pancreatic cancerresearch and discuss the latest combinations of pancreatic cancer biomarkers and their efficacy.

Keywords： pancreatic cancer     cancer screening     single cell     molecular alterations     precancerous lesion     therapy    

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Title Author Date Type Operation

Clinical Correlates and Prognostic Value of Different Metastatic Sites in Gastric and Colorectal Signet

Jingjing Wu, Daiqiong Fang, Da Man, Wenrui Wu, Qing Wang, Yating Li, Jianzhong Ye, Lanjuan Li

Journal Article

Effect of gastric fluid on adsorption and desorption of endocrine disrupting chemicals on microplastics

Journal Article

From gut changes to type 2 diabetes remission after gastric bypass surgeries

Bing Li, Xinrong Zhou, Jiarui Wu, Huarong Zhou

Journal Article

MSI/LOH and extron expression of the FHIT gene in gastric carcinoma

XIAO Yuping, MAO Lili, HAN Chengbo, LI Jinyi, XU Lei, XIN Yan

Journal Article

Effect of oxytocin on gastric ischemia-reperfusion injury in rats

ZHANG Wenwen, ZHANG Jianfu, ZHANG Yongmei, XU Ming

Journal Article

Data mining of microarray for differentially expressed genes in liver metastasis from gastric cancer

Ling XU MM, Feng WANG MM, Xuan-Fu XU MD, Wen-Hui MO BM, Rong WAN MD, Chuan-Yong GUO MD, Xing-Peng WANG MD,

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article

Characterization of the Gastric Mucosal Microbiota in Patients with Liver Cirrhosis and Its Associations

Yanfei Chen, Jing Guo, Chunlei Chen, Ding Shi, Daiqiong Fang, Feng Ji, Lanjuan Li

Journal Article

Progress and challenges in RET-targeted cancer therapy

Journal Article

Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination

Lei Huang,Aman Xu

Journal Article

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Journal Article

Metformin for cancer prevention

Yonghua Yang

Journal Article

Orlistat induces ferroptosis-like cell death of lung cancer cells

Journal Article

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Journal Article

Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Journal Article